J04 : QSAR Model for the Inhibition of A-Beta1-42 Peptide: Molecular Dynamics and Bioinformatics Study
| Students | Becca Barbera
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| School | HWCD - Cathedral High School - Hamilton |
| Level | Senior 11/12 - Grade 12 |
| Group | Group 9 - Health Sciences III |
| Abstract | Amyloid-Beta1-42 (A-Beta1-42), a cytotoxic peptide that accumulates in, and defunctionalizes, a variety of major organs, has been presented as the cause of several diseases, such as congestive heart failure, Alzheimer’s, myeloma, and nephrotic syndrome. The purpose of this study is to develop a Quantitative Structure-Activity Relationship model, that accurately predicts the efficiency of any phenyl-related molecule to inhibit the aggregation of A-Beta1-42 within the body. |